As the world's population grows, improving the value of crops and livestock is essential. To do so requires an in-depth understanding of genetic variation and how it relates to traits of interest. Such understanding starts with high quality data, but it's made possible through powerful analytics.
Our SNP & Variation Suite™ (SVS) software delivers a world-class analytic tool and powerful visualizations in a user-friendly interface. No more struggling to coerce command-line software -- designed exclusively for human genetics -- to work for the plant or animal species you're studying. SVS supports a wide variety of analysis methods for a wide variety of species enabling you to quickly and easily identify variants related to pest and disease resistance, increased feed efficiency, milk production, and more.
Our software tools manage, analyze, visualize and filter data all through a friendly user interface. We take great care in researching and implementing best practices as well as the latest methods and algorithms and serve them up in an intuitive way. We eliminate the need to learn how to script, unless you want to. While SVS provides a flexible, user-friendly interface on the front-end, it also provides full programmatic access on the back-end. So whether you're one who shudders at the thought of writing another line of code, or one who lives for it, SVS empowers you to do more than you ever thought possible.
SVS supports the broadest array of data formats for both import and export, eliminating the hassles of working with large data. You'll also find a host of tools that make it easy to format and recode data, merge data sets, create subsets, and more.
Support for a Wide Variety of Species and Genomes
No more coercing software designed for human genetics to work with the plant or animal species you're studying. SVS supports a wide variety of species, including different genomic builds for some. If your particular species is not included by default, you can easily add it along with corresponding annotations from a point-and-click interface. And switching between species and genomes is easy too. Just select the species you're studying from the project options tab or from a drop down menu in the genome browser and you're ready to go. See the full list of animal and plant genomes available in Golden Helix® software here.
VarSeq provides coverage metrics in two forms. First, each variant displays data about the region in which it resides. This binding allows variants from suspect regions to be flagged or filtered out, which can help to prevent false positives. Second, each region in the BED file can be examined. This mode of analysis ensures that all the targeted regions were sequenced, which is crucial to preventing false negatives.
Clinical grade variant annotations
Included in VarSeq is functionality similar to SnpEff or Variant Effect Predictor. Each variant is mapped to all overlapping transcripts and information about the region where it is located (exon, intron, intergenic, etc.), sequence ontology (frame shift, synonymous, etc.), and HGVS notation (g dot, c dot, and p dot) is provided. You can chose to filter against the highest-impact annotation for each variant or the entire set of variant-transcript interactions.
Genome-Wide Association Studies (GWAS)
GWAS is growing rapidly in agricultural applications as a very effective method to identify genes of interest such as those affecting production and resistance traits. SVS provides you with a number of intuitive workflows from basic to advanced SNP analyses to lead you beyond single marker associations. With support for case-control and quantitative traits, whole genome and candidate gene data, you can run a breadth of statistical tests under several genetic models. Advanced regression can further help elucidate even the most complex gene-gene and gene-environment interactions. See the full description of our GWAS capabilities here.
Whether you are using candidate genes or whole genomes, microarrays or next-generation sequencing, SVS delivers unparalleled performance on any size data. You can seamlessly navigate spreadsheets with billions of data points and easily plot variant maps, heat maps and genomic annotations across the entire genome for thousands of samples.
SVS provides the most complete set of statistical and visual analytic tools to help you quickly identify genetic variants or haplotypes and their association with traits of interest. We support SNP, CNV, or sequence data allowing you to perform a wide range of analyses. Not to mention all the time you'll save by not having to move large, complex datasets between multiple packages.
All visualizations in SVS are dynamic, interactive and integrative so you can quickly identify hot spots and navigate to areas of interest. Compare variant maps, LD structure or copy number patterns among breeds. Produce Manhattan plots for any number of dependent variables. Assess identity by descent or population stratification to locate problematic samples. The best part: any genomic-based plot can be visualized in an interactive genome browser alongside relevant annotations with proper genomic coordinates for the species you're studying.
Speed and Flexibility
Genomic Prediction is quickly becoming one of the most used tools for researchers interested in milk production, weight gain, and marbling or increased yield. SVS allows researchers to determine which animals or plants to continue breeding for desired traits including various means of defining the relationship between samples, the ability to validate models and visualize the results. See our full Genomic Prediction capabilities here.
Comprehensive Quality Assurance
High quality data is critical to high quality results. To ensure your data is of the highest quality, SVS provides the most comprehensive set of quality assurance tools helping you to not only assess the quality of your data, but remedy any problems as well.
- Wickramasinghe, S et al. (2011) Variants in the pregnancy-associated plasma protein-A2 gene on Bos taurus autosome 16 are associated with daughter calving ease and productive life in Holstein cattle. Journal of Dairy Science, 94(3):1552-1558, doi:10.3168/jds.2010-3237.
Read the Abstract
- Rincon, G et al. (2009) Fine mapping and association analysis of a quantitative trait locus for milk production traits on Bos taurus autosome 4. Journal of Dairy Science, 92:758-764. doi:10.3168/jds.2008-1395.
Read the Abstract
- Rincon, G et al. (2011) Comparison of buccal and blood-derived canine DNA, either native or whole genome amplified, for array-based genome-wide association studies. BMC Research Notes, 4:226, doi:10.1186/1756-0500-4-226.
Read the Abstract
- Go, Y et al. (2011) Genome-Wide Association Study Among Four Horse Breeds Identifies a Common Haplotype Associated with the In Vitro CD3+ T Cell Susceptibility/Resistance to Equine Arteritis Virus Infection. Journal of Virology, doi:10.1128/JVI.06068-11.
Read the Abstract
- Dillon, S et al. (2013) Signatures of adaptation and genetic structure among the mainland populations of Pinus radiata (D. Don) inferred from SNP loci. Tree Genetics & Genomes, doi:10.1007/s11295-013-0650-8.
Read the Abstract
- Emanuelli, F et al. (2010) A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.). BMC Plant Biology, 10:241, doi:10.1186/1471-2229-10-241.
Read the Abstract
We know our software will exceed your expectations. But don't just take it from us, see what our customers have benefitted from it.
Dr. Benjamin Darbro
Director, Shivanand R. Patil Cytogenetics and Molecular Laboratory
VarSeq had everything we were looking for with regards to annotation, filtering sources and an actual visual browser within the software itself. VSReports allows us to take it all the way to the report generation. But what really set it apart in retrospect is how intuitive it is.Read Dr. Darbro's Entire Case Study
Dr. Matthew McClure
Lead Geneticist, Irish Cattle Breeding Federation
Dr. Matthew McClure is a lead geneticist at the Irish Cattle Breeding Federation, and was previously at the Bovine Functional Genomics Lab at the USDA-ARS. In the case study, Dr. McClure talks about using SVS at the ICBF and the results he's been able to achieve. In the webcast, Dr. McClure describes his research at the USDA-ARS to identify causal mutations for Mendelian and complex traits.Read Dr. McClure's Entire Case Study
Dr. Chaim Jalas
Director, Genetic Resources & Services
Paying per sample fees is too much. I would rather buy a software program than to ever think twice before reanalyzing a sample. It also makes budgeting less of a hassle. And Golden Helix has been around for a long time. I know that you will not disappear in a few months.Read Dr. Jalas's Entire Case Study
Recommended Learning Materials
We have a variety of supplemental learning materials that are an excellent resource for anyone interested in the industry or our software solutions. Here are some of our recommended materials for you to check out related to VarSeq!
Check out our free eBooks on a variety of different topics:
Watch an informative webcast featuring VarSeq in action!Genomic Analyses for Palatability of Beef
Free SVS Viewer
Explore a genomic prediction sample project in SVS!