The Sentieon Genomic Tools - Improved Best Practices Pipelines for Analysis of Germline and Tumor-Normal Samples


Date: Wednesday, May 17, 2017

Presenters: Dr. Andreas Scherer, President & CEO, Golden Helix & Dr. Donald Freed, Bioinformatics Scientist, Sentieon

Duration: 35 Minutes

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Slides

Sentieon Secondary Analysis

Abstract

With next-generation sequence datasets frequently reaching petabytes in size, processing genomic data accurately and efficiently is increasingly a major computational bottleneck. The Sentieon Genomics Tools provide a solution to this bottleneck with a reimplementation of the mathematics underlying the GATK Best Practices pipelines for calling variants from germline or tumor-normal paired samples.

The Sentieon Genomics Tools provide identical results to the GATK pipelines with a 10x reduction in runtime, a robust software implementation, and deterministic data processing. This webcast will explore the benefits of the Sentieon Genomics Tools including a discussion of the results of the PrecisionFDA Truth and Consistency challenges and the ICGC-TCGA DREAM Mutation Calling Challenge for somatic SNV, indel, and structural variants.

Golden Helix has partnered with Sentieon to integrate its secondary analysis tools with Golden Helix software to provide users with a comprehensive solution for genomic data analysis. In this webinar, Dr. Andreas delves into the new partnership, followed by an overview of the Sentieon software by Dr. Donald Freed.

About the Presenters

Andreas Scherer

Dr. Andreas Scherer has managed global software and services businesses working for publicly traded companies such as Netscape and AOL as well as privately held companies. As part of his academic work, he has developed algorithms to conduct DNA sequence analysis. In the last decade, he has focused on accelerating R&D processes of Fortune 500 pharmaceutical, biotech, and medical device companies. As a result of this work, he is intimately familiar with the domestic and international life sciences market. Dr. Scherer holds a PhD in Computer Science from the University of Hagen, Germany, and a Master of Computer Science from the University of Dortmund, Germany. He is author and co- author of over 20 international publications and has written books on project management, the Internet, and artificial intelligence. Follow Andreas on Twitter @andreasscherer or connect with him on LinkedIn.

Donald Freed

Dr. Donald Freed is currently a Bioinformatics Scientist at Sentieon, Inc. He earned his Ph.D. in Neuroscience from the Johns Hopkins School of Medicine where he investigated the role of somatic mosaic mutations in autism. He is interested in deciphering genetics variants underlying human phenotypes and accurately processing large genomic datasets.